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Fujie Tanaka(2010). Enamine-Based Reactions: Strategies for the Development of Organocatalysts and Catalyzed Reactions. J. of SJWS 10: 1-9
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Enamine-Based Reactions: Strategies for the Development
of Organocatalysts and Catalyzed Reactions
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Fujie Tanaka
PInstitute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan,
and Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan, and
Faculty of Engineering, Gifu University
1-1 Yanagido, Gifu 501-1193, Japan
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Abstract: Enamines are key intermediates in both organic chemistry and enzyme catalysis. We have developed designer proteins and small peptides that catalyze aldol, retro-aldol, and Michael reactions, in which catalyst molecules form enamines from aldehydes and ketones in situ. We have also developed small amine- and amino acid-catalyzed enamine-based bond-forming reactions that can be performed under mild conditions. In this review, I summarize our strategies for the development of designer catalysts and catalyzed reactions that use enamines as key intermediates.
Key words: organocatalysis, designer enzymes, enamines, aldol reactions, asymmetric synthesis
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