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Kayo Masuko(2010). Expression of Prostaglandin E2 Receptors in Chondrocytes:a Potential Therapeutic Target in the Treatment of Osteoarthritis?. J. of SJWS 10: 47-51
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Expression of Prostaglandin E2 Receptors in Chondrocytes:
a Potential Therapeutic Target in the Treatment of Osteoarthritis?
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Kayo Masuko, MD, PhD1, Kazuo Yudoh, MD, PhD2, Hiroshi Nakamura, MD, PhD3
1 Department of Biochemistry, St. Marianna University School of Medicine, Kanagawa, Japan
2 Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan
3 Department of Rheumatology, Nippon Medical School, Tokyo, Japann
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Abstract: Accumulating data strongly suggest that prostaglandin E2 (PGE2) exerts a variety of bioactivity in articular chondrocytes via its receptors (EP receptors). In addition, it has been suggested that isoforms of the EP receptor, e.g. EP2 and EP4, play specific roles in matrix turnover in the cartilage, as well as chondrocyte differentiation and chondrogenesis. Here, we summarize recent reports on EP receptor expression and its potential role in articular chondrocytes and focus on its potential role in the pathophysiology of human osteoarthritis.
Key words: Articular chondrocytes, prostaglandin, EP receptor, osteoarthritis
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